Membranes and deoxyribonucleic acid of hippocampal neurons damage due to low-density polyethylene microplastics in blood of Wistar rats

Microplastic particles in the blood can cause damage to organs such as brain. This study aimed analyze effect of microplastic on membrane (expression malondialdehyde metabolites) and deoxyribonucleic acid 8-hydroxy-2?-deoxyguanosine hippocampus neurons Wistar rats. Methods: Forty-two rats were used equally divided into six groups. The groups X1, X2, X3, X4 X5 was given 0.0375mg, 0.075mg, 0.15mg, 0.3mg, 0.6mg low-density polyethylene powder mixed with 2cc distilled water respectively, while control group only water. administration carried out for 90 days. Results: found level microplastics particle higher along exposure dose. mean expression metabolites hippocampal CA1 CA3 areas significantly increased doses (Kruskal-Wallis test p <0.01). Spearmen’s correlation showed a strong relationship between levels (all has neurons.